Clozapine-Sertindole

Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine
Sertindole
Type Antipsychotic
Group Atypical AP
links
PubChem 60149
PubMed Sertindole
Kompas (Dutch) Sertindole
Wikipedia Sertindole

Switch medication from Clozapine to Sertindole.

Nietinrijdenbord.png Stop Clozapine
  • Day 1: Decrease daily dose with 25 mg every 2 days
Eenrichtingbord.png Start Sertindole
  • Week 1: approx. 25% of target dose
  • Week 2: approx. 50% of target dose
  • Week 3: approx. 75% of target dose
  • Week 4: target dose
Letopbord.png Cave
  • During this switch ECG monitoring is required because of possible QT-interval prolongation[1][2]
Infobord.png More information
  • Clozapine is generally considered to be more effective than other antipsychotic drugs. Clozapine is often used in treatment-resistant schizophrenia (poor treatment response to 2 or more antipsychotic drugs). So a switch from clozapine to another antipsychotic drug could cause problems regarding effectiveness.[3][4][5]
    StartStandDownClozapine.jpg
Nietinrijdenbord.png — Clozapine
Eenrichtingbord.png — Sertindole


  1. SPC Sertindole (Dutch)
  2. SPC Sertindole
  3. McEvoy J P et al., Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry. 2006;163:600–610.
  4. Lewis S W et al., Randomized Controlled Trial of Effect of Prescription of Clozapine Versus Other Second-Generation Antipsychotic Drugs in Resistant Schizophrenia. Schizophrenia Bulletin vol.32 no.4 pp.715–723,2006.
  5. Agid O, Kapur S, Remington G, Emerging drugs for schizophrenia. Expert Opin Emerg Drugs. 2008 Sep;13(3):479-95.
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