Combining-Risperidone-Valproic acid

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid

Adding valproic acid to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
Eenrichtingbord.png Start valproic acid
  • Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
  • Start valproic acid according to the general dosing advice.
Letopbord.png Cave
  • Dose-related generalised oedema is reported. [1]
  • Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. [2]


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