Fluoxetine-trazodone

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from fluoxetine to trazodone.[1][2]

Nietinrijdenbord.png Stop fluoxetine
  • Day 1: Stop fluoxetine
Eenrichtingbord.png Start trazodone
  • Day 5: Start with 50% of the target dose
  • Day 10: Increase dose to 100% of the target dose
  • Day 11 and after: Gradually increase dose as necessary
Infobord.png More information
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Fluoxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary for at least four weeks.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Safe target dose of trazodon as antidepressant = 150 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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