Paroxetine-amitriptyline

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from paroxetine to amitriptyline.[1][2]

Nietinrijdenbord.png Stop paroxetine
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start amitriptyline
  • Day 1: start administration of amitriptyline in a low dosage of 25mg/day.
  • Day 8: increase dosage of amitriptyline to a dosage of 50 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of amitriptyline via CYP2D6 inhibition.
  • Due to CYP inhibition a longer period of time is needed to reach steady state concentration. Please keep in mind when monitoring plasma levels
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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