Risperidone-Clozapine

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine

Switch medication from Risperidone to Clozapine.

Nietinrijdenbord.png Stop Risperidone
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Clozapine
  • Day 1: start with 12,5 mg at night
  • Day 2: 25 mg in divided doses
  • Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
  • Day 16-28: if necessary, increase dose with 50-100 mg/week
  • Low dose in the morning, high dose at night (twice daily dosage)
  • Increments are dependent on the status of patient
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[4]
    Stopstandaardstartclozapine.jpg
Nietinrijdenbord.png — Risperidone
Eenrichtingbord.png — Clozapine


  1. 1.01.1 KNMP; Informatorium Medicamentorum 2015; Monografie "risperidon" (Dutch)
  2. Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  3. 3.03.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  4. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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