Olanzapine-Aripiprazole

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole

Switch medication from Olanzapine to Aripiprazole.

Nietinrijdenbord.png Stop Olanzapine
  • Week 1: approx. 75% of initial dose
  • Week 2: approx. 50% of initial dose
  • Week 3: approx. 25% of initial dose
  • Week 4: approx. 12,5% of initial dose
  • Day 28: stop
Eenrichtingbord.png Start Aripiprazole
  • Day 1-3: start 50% of target dose
  • Day 4-7: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[4]
    Anticholinerg AP naar partieel2.jpg
Nietinrijdenbord.png — Olanzapine
Eenrichtingbord.png — Aripiprazole


  1. 1.01.11.21.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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