Switch medication from Olanzapine to Risperidone_LA.
- Day 1-14: Continue drug at usual dose
- Day 15-18: approx. 75% of initial dose
- Day 19-22: approx. 50% of initial dose
- Day 23-27: approx. 25% of initial dose
- Day 28: stop
- Day 1: Start depot according general dosing advice (Dotted line in graph)
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
- Alternatively, first switch to oral form and then switch to depot to manage possible (adverse) reactions. With a direct switch to a depot it is advisable to administer a low testdose in order to exclude adverse reactions.
- KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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