Amisulpride-Clozapine

Amisulpride
Type Antipsychotic
Group Atypical AP
links
PubChem 2159
PubMed Amisulpride
Wikipedia Amisulpride
Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine

Switch medication from Amisulpride to Clozapine.

Nietinrijdenbord.png Stop Amisulpride
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Clozapine
  • Day 1: start with 12,5 mg at night
  • Day 2: 25 mg in divided doses
  • Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
  • Day 16-28: if necessary, increase dose with 50-100 mg/week
  • Low dose in the morning, high dose at night (twice daily dosage)
  • Increments are dependent on the status of patient
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    Stopstandaardstartclozapine.jpg
Nietinrijdenbord.png — Amisulpride
Eenrichtingbord.png — Clozapine


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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