Switch medication from clomipramine to maprotiline.
- Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1: when a dosage of 75 mg/day is reached, stop administration.
- No wash-out period is needed.
- Day 2: start administration of maprotiline in a normal dosage of 25-75 mg/day.
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