Clozapine-Penfluridol

Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine
Penfluridol
Type Antipsychotic
Group Atypical AP
links
PubMed Penfluridol
Wikipedia Penfluridol

Switch medication from Clozapine to Penfluridol.

Nietinrijdenbord.png Stop Clozapine
  • Week 1: approx. 75% of initial dose
  • Week 2: approx. 50% of initial dose
  • Week 3: approx. 25% of initial dose
  • Week 4: approx. 12,5% of initial dose
  • Day 28: stop
Eenrichtingbord.png Start Penfluridol
  • Week 1: start with 10 mg
  • Week 2: increase dose to 20 mg
  • Week 3 and further: adjust dose according to clinical presentation
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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