Adding gabapentin to carbamazepine.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- Start gabapentin according to the general dosing advice. Coadministration of carbamazepine with gabapentin appears to be safe, with no significant interactions. Dose adjustments and additional blood level monitoring are not necessary.
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.
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