Adding carbamazepine to gabapentin.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Start carbamazepine according to the general dosing advice.Coadministration of carbamazepine with gabapentin appears to be safe, with no significant interactions. Dose adjustments and additional blood level monitoring are not necessary.
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. 
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