Adding lithium to lamotrigine.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- This combination of drugs may be rational, but more data is needed..
- Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. 
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
Farmacotherapeutisch Kompas - lamotrigine (dutch)
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- Drugs.com lamotrigine
- Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- 10971302 Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5
- Interactions between lamotrigine and lithium on drugs.com
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