Adding olanzapine to lamotrigine.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
- Start lamotrigine according to the general dosing advice.
- Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. 
Farmacotherapeutisch Kompas; Toxicologie (dutch)
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- Farmacotherapeutisch Kompas - lamotrigine (dutch)
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- KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
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