Adding risperidone to lamotrigine.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
- Start risperidone according to the general dosing advice.
- A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. 
- Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. 
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