Adding risperidone to olanzapine.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive effects when used in combination. 
KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- Interactions between risperidone and olanzapine on drugs.com
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