Adding olanzapine to quetiapine.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive effects when used in combination. 
KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content
- NVZA; Toxicology.org; Monografie 73 (dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- Drugs.com quetiapine-fumarate
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- Interactions between olanzapine and quetiapine on drugs.com
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