Adding gabapentin to topiramate.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
- Start gabapentin according to the general dosing advice.
Farmacotherapeutisch Kompas - topiramaat (dutch)
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