Switch medication from doxepin to agomelatine.
- Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of doxepin to 50 mg/day.
- Day 8: reduce dosage of doxepin to 25 mg/day.
- Day 15: stop administration of doxepin.
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
- KNMP; Informatorium Medicamentorum 2015; Monografie "doxepine" (Dutch)
- NVZA; Toxicology.org; Monografie 63 (dutch)
- McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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