Switch medication from escitalopram to agomelatine.
- Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is >10 mg/day.
- Day 1: reduce dosage of escitalopram to a maximum of 5 mg/day.
- Day 8: stop administration of escitalopram.
- Day 9: start administration of agomelatine in a dosage of 25 mg/day.
- Day 16: if necessary, increase dosage of agomelatine to 50 mg/day.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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