Fenelzine-agomelatine

Fenelzine
Type Antidepressant
Group MAO-I
links
PubMed Fenelzine
Kompas (Dutch) Fenelzine
Wikipedia Fenelzine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from fenelzine to agomelatine[1][2]

Nietinrijdenbord.png Stop fenelzine
  • Day 1: decrease the original dose with about 25% every 3 days.
  • Day 9: stop administration of fenelzine.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[3]
  • If necessary, increase dosage of agomelatine to 50 mg/day.
Infobord.png More information
  • After the last dose of tranylcypromine and/or fenelzine it takes about 14 days to restore the activity of the MAO enzymes[4]
  • Fenelzine has to be phased out to avoid withdrawal symptoms.[5]


  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
  4. ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "fenelzine" (Dutch)
  5. ↑ Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
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