Hypericum-paroxetine

Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from hypericum to paroxetine.

Nietinrijdenbord.png Stop hypericum
  • Day 1-14: Gradually decrease the dosage of hypericum.
  • Day 15: Stop administration of hypericum.
Eenrichtingbord.png Start paroxetine
  • Day 15-22: A wash-out period of at least one week is necessary.[1][2][3][4]
  • Day 23: Start paroxetine 20 mg/day.
  • Day 44: If necessary increase dosage to 30-50 mg/day.
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[5]
  • The T1/2 of hypericum is 19 - 37 hour.[4]
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