Hypericum-sertraline

Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from hypericum to sertraline.

Nietinrijdenbord.png Stop hypericum
  • Day 1-14: Gradually decrease the dosage of hypericum.
  • Day 15: Stop administration of hypericum.
Eenrichtingbord.png Start sertraline
  • Day 15-22: A wash-out period of at least one week is necessary.[1][2][3][4]
  • Day 23: Start sertraline 25 mg/day.
  • After day 44: If necessary increase dosage gradually to 50-200 mg/day
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[5]
  • The T1/2 of hypericum is 19 - 37 hour.[4]
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