Rest AP-Pimozide

Rest anti-psychotics

Chlorprothixene
Flupentixol
Loxapine
Paliperidone
Pericyazine
Perphenazine
Trifluoperazine
Zuclopenthixol

Pimozide
Type Antipsychotic
Group Diphenylbutylpiperidines
links
Medscape Pimozide
PubChem 16362
PubMed Pimozide
Kompas (Dutch) Pimozide
Wikipedia Pimozide

Switch medication from Rest AP to Pimozide.

Nietinrijdenbord.png Stop Rest AP
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Pimozide
  • Day 1-4: approx. 50% of target dose
  • Day 5-8: approx. 75% of target dose
  • Day 9: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    StartdubbelStopstand.jpg
Nietinrijdenbord.png — Rest AP
Eenrichtingbord.png — Pimozide


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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