Type antidepressant
Group TCA
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Nietinrijdenbord.png Stop dosulepin
  • In general after long-term maintenance treatment, the best is to reduce the dose by about 25% every 4-6 weeks. An apt pharmaceutical dose (tablet, capsule, mixture) is not always available. In these cases one should be creative with dosing.[3][4]
  • Another, more risky, possibility is being at a certain dose to use the following scheme:[5]
  • 150 mg/day:
  • Day 1: reduce dosage of dosulepin to 100 mg/day.
  • Day 8: reduce dosage of dosulepin to 75 mg/day.
  • Day 15: reduce dosage of dosulepin to 50 mg/day.
  • Day 22: reduce dosage of dosulepin to 25 mg/day.
  • Day 29 stop the administration of dosulepin.

  1. KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
  2. NVZA;; Monografie 63 (dutch)
  3. The UK Drug and Therapeutics Bulletin; 1999;37:49-52
  4. Editor: please note that not all dosages are available in pharmacy. So now and then you should be creative.
  5. Bazire S, Psychotropic Drug Directory 2010. Aberdeen: HealthComm UK Ltd; 2010.
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