Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine

Nietinrijdenbord.png Stop tranylcypromine
  • In general after long-term maintenance treatment, the best is to reduce the dose by about 25% every 4-6 weeks. An apt pharmaceutical dose (tablet, capsule, mixture) is not always available. In these cases one should be creative with dosing.[1][2]
  • Another, more risky, possibility is being at a certain dose to use the following scheme:
  • 60 mg/day [3]:
  • Day 1: reduce dosage of tranylcypromine to 50 mg/day.
  • Day 8: reduce dosage of tranylcypromine to 40 mg/day.
  • Day 15: reduce dosage of tranylcypromine to 30 mg/day.
  • Day 22: reduce dosage of tranylcypromine to 20 mg/day.
  • Day 29: reduce dosage of tranylcypromine to 10 mg/day.
  • Day 36: stop administration of tranylcypromine.

  1. The UK Drug and Therapeutics Bulletin; 1999;37:49-52
  2. Editor: please note that not all dosages are available in pharmacy. So now and then you should be creative.
  3. Bazire S, Psychotropic Drug Directory 2010. Aberdeen: HealthComm UK Ltd; 2010.
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