Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group SMS
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from tranylcypromine to vortioxetine.

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1-14: decrease the original dose with about 25% every 3 days.
Eenrichtingbord.png Start vortioxetine
  • A wash-out period of two weeks is necessary.
  • Day 28: start administration of vortioxetine in a normal dosage of 10 mg/day. [1]
Letopbord.png Cave
  • Occurrence of the serotonin syndrome is possible without a wash-out period.
Infobord.png More information
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
  1. KNMP; Informatorium Medicamentorum 2015; Monografie "tranylcypromine" (Dutch)
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