Switch medication from venlafaxine to agomelatine.
- Before day 1: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
- Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day or 75 mg slow release.
- Day 8: stop administration of venlafaxine.
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 8: continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
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