Switch medication from vortioxetine to tranylcypromine.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- Day 8-21: a wash-out period of two weeks is necessary.
- Day 22: Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
- Day 29: after this week the dosage of tranylcypromine can be increased if necessary.
- Occurrence of the serotonin syndrome is possible without wash-out period.
- Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- KNMP; Informatorium Medicamentorum 2015; Monografie "vortioxetine" (Dutch)
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