Combining-Aripiprazole-Valproic acid

Aripiprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
Medscape Aripiprazole
EMEA abilify
PubChem 60975
PubMed Aripiprazole
Kompas (Dutch) Aripiprazole
Wikipedia Aripiprazole
Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid

Adding valproic acid to aripiprazole.

Infobord.png General information
  • Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.

 

Eenrichtingbord.png Start valproic acid
  • Start according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.[1]
  • Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. [2]


  1. Interactions between aripiprazole and valproic acid on drugs.com
  2. Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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