Combining-Valproic acid-Lithium

Valproic acid
Type moodstabilizer
Group anticonvulsant
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Type moodstabilizer
Group other
ATC-code N05AN01
Medscape Lithium
PubChem 11125
PubMed Lithium lithium
Kompas (Dutch) Lithium
Wikipedia Lithium

Adding lithium to valproic acid.

Infobord.png General information
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
  • Lithium and valproic acid are the most commonly used mood-stabilizing agents.[1]
  • The combination of lithium and valproate appears to be well tolerated and effective in treating bipolar illness.[1]
  • Addition of lithium to valproic acid is the treatment of choice for acute mania with partial but inadequate response to valproate.[1]
  • This combination may be synergistic.[1]
  • Lithium’s pharmacokinetics are not changed by valproate.[1]
  • There may be additive adverse reactions due to this combination, such as weight gain, sedation, gastrointestinal complaints, and tremor.[1]
Eenrichtingbord.png Start lithium
  • Start lithium acid according to the general dosing advice.

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