Adding quetiapine to carbamazepine.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. 
- Add quetiapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. 
- ↑ Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91
- ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
- ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
- ↑ Interactions between carbamazepine and quetiapine on drugs.com
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