Combining-Quetiapine-Carbamazepine

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to quetiapine.

Infobord.png General information
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Start carbamazepine according to the general dosing advice.
  • The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.[1]
Letopbord.png Cave
  • Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. [2]


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